Chrobok Lab - Daily changes in neuronal activities of the dorsal motor

Journal article

L. Chrobok, J. D. Klich, J. S. Jeczmien-Lazur, K. Pradel, K. Palus-Chramiec, A. Sanetra, H. Piggins, M. Lewandowski
Journal of Physiology, 2021

Semantic Scholar DOI PubMed

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APA Click to copy
Chrobok, L., Klich, J. D., Jeczmien-Lazur, J. S., Pradel, K., Palus-Chramiec, K., Sanetra, A., … Lewandowski, M. (2021). Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and high‐fat diet. Journal of Physiology.

Chicago/Turabian Click to copy
Chrobok, L., J. D. Klich, J. S. Jeczmien-Lazur, K. Pradel, K. Palus-Chramiec, A. Sanetra, H. Piggins, and M. Lewandowski. “Daily Changes in Neuronal Activities of the Dorsal Motor Nucleus of the Vagus under Standard and High‐Fat Diet.” Journal of Physiology (2021).

MLA Click to copy
Chrobok, L., et al. “Daily Changes in Neuronal Activities of the Dorsal Motor Nucleus of the Vagus under Standard and High‐Fat Diet.” Journal of Physiology, 2021.

BibTeX Click to copy

@article{l2021a,
  title = {Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and high‐fat diet},
  year = {2021},
  journal = {Journal of Physiology},
  author = {Chrobok, L. and Klich, J. D. and Jeczmien-Lazur, J. S. and Pradel, K. and Palus-Chramiec, K. and Sanetra, A. and Piggins, H. and Lewandowski, M.}
}

Abstract

Recently, we found that the dorsal vagal complex displays autonomous circadian timekeeping properties The dorsal motor nucleus of the vagus (DMV) is an executory part of this complex – a source of parasympathetic innervation of the gastrointestinal tract Here, we reveal daily changes in the neuronal activities of the rat DMV, including firing rate, intrinsic excitability and synaptic input – all of these peaking in the late day Additionally, we establish that short term high‐fat diet disrupts these daily rhythms, boosting the variability in the firing rate, but blunting the DMV responsiveness to ingestive cues These results help us better understand daily control over parasympathetic outflow and provide evidence on its dependence on the high‐fat diet